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IPC:G01N
NAICS:541710

Nanoliter Lab-On-a-Chip Powered By Digital Microfluidics

Advanced Liquid Logic
  • Technology Description

    Advances in engineering have made possible new approaches to liquid handling based on microscale phenomena which are suitable for miniaturization and automation in a “microfluidic chip”. Advanced Liquid Logic’s unique and patented digital microfluidic technology promises to transform this emerging field by enabling the world’s most integrated, flexible, and portable lab-on-a-chip systems for miniaturizing and automating an enormous array of liquid-based laboratory, medical, and other analyses. Advanced Liquid Logic is spearheading developments in this platform technology and has the intellectual property position and the team to take advantage of that position.

    Digital microfluidics is an alternative paradigm for liquid handling based on electrical micromanipulation of discrete droplets. This disruptive technology offers an order of magnitude generational leap in liquid handling function. Like digital microelectronics, basic instruction sets can be combined and reused within heirarchical software-based design structures so that complex procedures (e.g. chemical synthesis or biological assays) can be built up step-by-step. In contrast to continuous-flow or channel-based microfluidics, digital microfluidics works much the same way as traditional bench-top protocols, only with much smaller liquid volumes and supporting equipment and much greater flexibility and automation. Advanced Liquid Logic is in the process of transferring a wide range of established chemistries and protocols – including clinical chemistry, immunoassays, PCR, gene sequencing, and chemical synthesis - into a nanoliter droplet format for medical diagnostics. A myriad of other applications for this new and exciting technology will follow.

  • Value Proposition

    Microfluidics can dramatically reduce the cost per test for most analytical test processes. Advanced Liquid Logic's droplet-based digital microfluidics - since the system is electronically and software controlled (no pumps or valves)- can also bring the test to the point of sample collection: to the research lab, to the clinic, to the field, to the factory. Digital microfluidics will be the technology that fully enables lab-on-a-chip at the point of sample collection at gets test results here, and now - not in some central lab three days from now.

    While this platform technology could be applied to literally dozens of products in several multi-billion dollar markets including medical diagnostics, drug discovery, environmental monitoring, and more, Advanced Liquid Logic is focusing its development resources on two distinct but related markets - research instrumentation and medical diagnostics. The Company's first products will replace manual testing or robotic pipettors in drug discovery processes or other laboratory testing. Ideal customers would be academic or commercial researchers that want to miniaturize and/or automate a test process at a low cost of entry. For example, an academic researcher that wants to perform automated screens for protein crystallization using the Fluidigm Topaz system would pay about $100,000 for equipment and then supplies costs of $10 per well. We will be able to provide better data and make excellent margins at a price under $5,000 for equipment and supplies costs under $.05 per well. This will not only disrupt competitive offerings but will also allow many more researchers to crystallize their own proteins, which in turn could dramatically accelerate the drug discovery process. On the medical diagnostics side we will create robust handheld or bench top analyzers for infectious disease detection and other medical diagnostic applications. An ideal user would be a healthcare worker in a city health clinic or in the bush in Africa, where test results here and now are crucial: if the sample is sent to a central lab for results three days later, the healthcare worker may never see the patient again to begin treatment. The Company is currently in discussion with several potential commercial partners for implementation of the technology in various applications and has two contracts for prototype product development.

  • Competitive Analysis

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  • Video Introduction

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  • Company Capsule

    Advanced Liquid Logic

    615 Davis Dr, Suite 800
    PO Box 14025
    Research Triangle Park,
    NC 27709

    919-287-9010
    www.liquid-logic.com

    Advanced Liquid Logic’s digital microfluidics allows fluid handling to be broken down into discrete programmable manipulations of fluid nanodroplets which are electrically manipulated to dispense, transport, split, and mix under computer control. The platform is both reconfigurable and scalable, allowing many different types of assays to be performed on a general-purpose chip. The equipment required to drive the chip can be simpler than a PDA. Advanced Liquid Logic, a well-funded, twenty-person company, has implemented several medical diagnostic assays on chip and will have fully functional prototypes of multiple products in the hands of potential partners in early 2007.

  • Commercialization Team

  • Market Projection

    180?rand=296030
    2007 2008 2009 2010 2011
    Market Size $0.0 $9600000.0 $25100000.0 $100500000.0 $223000000.0
    Market Share (%) 0.0% 10.0% 15.0% 20.0% 25.0%